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Avidity-driven binding of ACE2 decoys to SARS-CoV-2 <t>Wuhan</t> (WT) strain spike <t>RBD</t> increases with higher ACE2 valency.
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Avidity-driven binding of ACE2 decoys to SARS-CoV-2 <t>Wuhan</t> (WT) strain spike <t>RBD</t> increases with higher ACE2 valency.
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Avidity-driven binding of ACE2 decoys to SARS-CoV-2 <t>Wuhan</t> (WT) strain spike <t>RBD</t> increases with higher ACE2 valency.
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Image Search Results


Avidity-driven binding of ACE2 decoys to SARS-CoV-2 Wuhan (WT) strain spike RBD increases with higher ACE2 valency.

Journal: mAbs

Article Title: Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

doi: 10.1080/19420862.2023.2212415

Figure Lengend Snippet: Avidity-driven binding of ACE2 decoys to SARS-CoV-2 Wuhan (WT) strain spike RBD increases with higher ACE2 valency.

Article Snippet: His-tagged spike RBD proteins for Wuhan (WT) (#10500-CV, R&D Systems), Delta (B.1.617.2) (#10876-CV, R&D Systems), Omicron (B.1.1.529) (#40592-V08H121, Sino Biological), Alpha (B.1.1.7) (#10730-CV, R&D Systems), Beta (B.1.351) (#10735-CV, R&D Systems), and Gamma (P.1) (#10775-CV, R&D Systems) were each covalently immobilized on a CM5 Series S sensor chip by amine coupling to ligand density of ~ 100 RU.

Techniques: Binding Assay

Binding kinetics of ACE2 decoy variants and clinical comparators to recombinant spike protein  RBD  as measured by SPR.

Journal: mAbs

Article Title: Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

doi: 10.1080/19420862.2023.2212415

Figure Lengend Snippet: Binding kinetics of ACE2 decoy variants and clinical comparators to recombinant spike protein RBD as measured by SPR.

Article Snippet: His-tagged spike RBD proteins for Wuhan (WT) (#10500-CV, R&D Systems), Delta (B.1.617.2) (#10876-CV, R&D Systems), Omicron (B.1.1.529) (#40592-V08H121, Sino Biological), Alpha (B.1.1.7) (#10730-CV, R&D Systems), Beta (B.1.351) (#10735-CV, R&D Systems), and Gamma (P.1) (#10775-CV, R&D Systems) were each covalently immobilized on a CM5 Series S sensor chip by amine coupling to ligand density of ~ 100 RU.

Techniques: Binding Assay, Recombinant, Control